Alzheimer’s drug trial test used for 20 years appears worthless
2012 12 18

By Sherry Baker | NaturalNews.com

What if a test of thinking abilities used to analyze whether Big Pharma drugs can help slow or treat Alzheimer’s weren’t actually accurate? And what if researchers had been relying on this screwed up test for decade upon decade? As amazing as it sounds, that appears to be the case.

Research led by Plymouth University Peninsula Schools of Medicine and Dentistry concludes the cognitive test used in Alzheimer’s drug trials is flawed. It’s so flawed, in fact, that it doesn’t track changes in the early stages of memory robbing Alzheimer’s disease. Why is this so extraordinarily important? Because data from this key stage is necessary to show whether or not a new drug works.

The test in question is the Alzheimer’s Disease Assessment Scale Cognitive Behavior Section (ADAS Cog). Developed back in the 1980s, it’s made up of 11 component parts including memory tests, language skills, naming objects and responding to commands. Patients are scored on each section resulting in a single overall score. The lower the total score, the better their cognitive performances are supposed to be. Until now, the ADAS Cog test was considered sort of a "gold standard" for assessing changes in thinking abilities as Alzheimer’s supposedly starts to destroy a person’s memory.

But the new research, published as two studies in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, which investigates the role of the test, questions its effectiveness. The results show that the assumed-accurate-for-decades ADAS Cog doesn’t work to track changes in the early stages of Alzheimer’s. Based on their findings, the Plymouth-based research team is calling for urgent changes to the ADAS Cog test. They are also not ruling out the possible need to throw the whole thing out and start over with a new test, either.

"It is impossible to say precisely the extent to which the ADAS Cog’s flaws have undermined the numerous clinical trials in which it has been used," Professor Jeremy Hobart, who headed the study, said in a media statement.

"It has been used, unchanged, for many years and its apparent contribution to suboptimal trials has led a number of drug companies to rethink their strategies. However, it is very clear that in its current form the ADAS Cog underestimates cognitive differences between people and changes over time," Hobart added. "To determine if treatments, developed from painstaking years of research, work in expensive studies we need to invest in developing measurement instruments that are fit for purpose. This requires the routine use of different methods. In its current form, the ADAS Cog is not working in people with mild Alzheimer’s disease."

While the drug companies have made little progress coming up with ways to halt or reverse Alzheimer’s disease, there is research that suggests natural health approaches can help. For example, as Natural News has previously covered, scientist William B. Grant, PhD, of the Sunlight, Nutrition, and Health Research Center (SUNARC) has come up with a hypothesis about the cause of mind-robbing Alzheimer’s disease and other vascular dementias: vitamin D deficiency.

Sources:

http://www.eurekalert.org/pub_releases/2012-12/uop-fia121412.php
http://www.naturalnews.com/026392_Vitamin_D_Alzheimers_disease.html
http://www.naturalnews.com/Alzheimers.html



Article from: naturalnews.com



Related Articles
Coconut Oil Touted as Alzheimer’s Remedy
GPS shoes for Alzheimer’s patients
Curry may prevent Alzheimer’s disease expert says
Earliest signs of Alzheimer’s found in 20-something year olds. Provides hints for prevention treatments


Latest News from our Front Page

Group Polarization and the Fad of Ethno-masochism
2014 11 26
From "Group polarization: A critical review and meta-analysis". Journal of Personality and Social Psychology. 6 50 (6): 1141--1151 The psychology of White self hatred. Political correctness IS a mental disorder. More: Group polarization: A critical review and meta-analysis. Isenberg, Daniel J. the paper Indoctrinate U Harvard Professor Noel Ignatiev talks about how to end the White race The History of Political Correctness The Narrative: The origins of Political ...
Credo: A Nietzschean Testament by Jonathan Bowden
2014 11 26
This lecture by Jonathan Bowden was given at the 11th New Right meeting in London on September 8, 2007. The original title of the presentation was “The Art and Philosophy of Jonathan Bowden.” I think ideas are inborn, and you’re attracted, if you have any, toward certain systems of thinking and sensibility and response. From a very young age, I was ...
A Look Back at the OJ Simpson Verdict -- Reactions
2014 11 26
This is a look back at the different reactions to the OJ Simpson verdict some 20 years ago (exact date of verdict was Oct 3, 1995). The OJ Simpson jury consisted of 9 Blacks, 1 Hispanic, and 2 Whites. It would raise eyebrows after they only deliberated for 4 hours in a case that they were involved in for almost ...
New York Times Publishes Darren Wilson’s Street Address and Photo of House #Ferguson
2014 11 26
Hey here are the two @nytimes scumbags that published Wilson’s home address. —> @juliebosman & @campbellnyt— Ben Howe (@BenHowe) November 25, 2014 Michael Brown’s Stepdad Shouting ‘Burn This Bitch Down’ The New York Times published information about the address of Ferguson Police Officer Darren Wilson on Monday in a move that has generated controversy. Tensions are running high in Ferguson, Missouri, as ...
How Monsanto is Destroying the Brains and Health of Everyone
2014 11 25
Interested in slowing your aging process? Take note! One of my most recent blog entries summarized roughly 10 years of research related to the consequences of inflammatory processes in the periphery of the body, such as the gut, and how this was driving brain degenerative inflammatory processes within the brain. One of the key findings from that research was how pathogenic ...
More News »