Alzheimer’s drug trial test used for 20 years appears worthless
2012-12-18 0:00

By Sherry Baker | NaturalNews.com

What if a test of thinking abilities used to analyze whether Big Pharma drugs can help slow or treat Alzheimer’s weren’t actually accurate? And what if researchers had been relying on this screwed up test for decade upon decade? As amazing as it sounds, that appears to be the case.

Research led by Plymouth University Peninsula Schools of Medicine and Dentistry concludes the cognitive test used in Alzheimer’s drug trials is flawed. It’s so flawed, in fact, that it doesn’t track changes in the early stages of memory robbing Alzheimer’s disease. Why is this so extraordinarily important? Because data from this key stage is necessary to show whether or not a new drug works.

The test in question is the Alzheimer’s Disease Assessment Scale Cognitive Behavior Section (ADAS Cog). Developed back in the 1980s, it’s made up of 11 component parts including memory tests, language skills, naming objects and responding to commands. Patients are scored on each section resulting in a single overall score. The lower the total score, the better their cognitive performances are supposed to be. Until now, the ADAS Cog test was considered sort of a "gold standard" for assessing changes in thinking abilities as Alzheimer’s supposedly starts to destroy a person’s memory.

But the new research, published as two studies in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, which investigates the role of the test, questions its effectiveness. The results show that the assumed-accurate-for-decades ADAS Cog doesn’t work to track changes in the early stages of Alzheimer’s. Based on their findings, the Plymouth-based research team is calling for urgent changes to the ADAS Cog test. They are also not ruling out the possible need to throw the whole thing out and start over with a new test, either.

"It is impossible to say precisely the extent to which the ADAS Cog’s flaws have undermined the numerous clinical trials in which it has been used," Professor Jeremy Hobart, who headed the study, said in a media statement.

"It has been used, unchanged, for many years and its apparent contribution to suboptimal trials has led a number of drug companies to rethink their strategies. However, it is very clear that in its current form the ADAS Cog underestimates cognitive differences between people and changes over time," Hobart added. "To determine if treatments, developed from painstaking years of research, work in expensive studies we need to invest in developing measurement instruments that are fit for purpose. This requires the routine use of different methods. In its current form, the ADAS Cog is not working in people with mild Alzheimer’s disease."

While the drug companies have made little progress coming up with ways to halt or reverse Alzheimer’s disease, there is research that suggests natural health approaches can help. For example, as Natural News has previously covered, scientist William B. Grant, PhD, of the Sunlight, Nutrition, and Health Research Center (SUNARC) has come up with a hypothesis about the cause of mind-robbing Alzheimer’s disease and other vascular dementias: vitamin D deficiency.

Sources:

http://www.eurekalert.org/pub_releases/2012-12/uop-fia121412.php
http://www.naturalnews.com/026392_Vitamin_D_Alzheimers_disease.html
http://www.naturalnews.com/Alzheimers.html



Article from: naturalnews.com



Related Articles
Coconut Oil Touted as Alzheimer’s Remedy
GPS shoes for Alzheimer’s patients
Curry may prevent Alzheimer’s disease expert says
Earliest signs of Alzheimer’s found in 20-something year olds. Provides hints for prevention treatments


Latest News from our Front Page

60 Years of Research Links Gluten Grains to Schizophrenia
2015-03-31 1:05
Does the consumption of gluten-containing grains contribute to psychiatric disorders such as schizophrenia? Believe it or not, this question has been asked for well over 60 years by researchers who stumbled upon evidence that the removal of gluten from the diet results in improved symptoms, or conversely, that gluten grain consumption leads to higher prevalence of both neurological and psychiatric problems. Reports ...
A Sour Deception: Citric Acid Comes From GMO Black Mold, Not Fruit
2015-03-30 23:32
Just what is your food made of, anyway? Try industrial synthesis, genetically modified mold secretions, hydrochloric acid, mercury-contaminated caustic soda, ferrocyanide… and, of course, lots of GMO corn. If common ingredients like “citric acid” and “ascorbic acid (Vitamin C)” sound normal and familiar enough that you practically conjure up an image of the flourishing orchard they were grown in – then ...
Thousands of migrants dumped on Britain as French wriggle out of border promise
2015-03-30 19:56
Thousands of migrants could be dumped on Britain’s doorstep if France tears up a historic border agreement, it was claimed last night. Officials have vowed to do “everything in their power” to wriggle out of a treaty moving the UK border to Calais. The besieged town’s mayor Natacha Bouchart is prepared to spark a major diplomatic row by opening the frontier ...
Richard III laid to rest at Leicester Cathedral
2015-03-30 18:36
King Richard III was today laid to rest at Leicester Cathedral - more than 500 years after his death in battle. The monarch, who reigned from 1483 to 1485, was the last of the Plantagenet dynasty. Actor Benedict Cumberbatch read a poem by Carol Ann Duffy during the service. Also in attendance was Robert Lindsay, who played Richard III in a version ...
Sweden - A new paradise for Romani beggars
2015-03-30 17:33
Thanks to the European Union and freedom of movement that follows with membership Sweden has been flooded with gypsies from Eastern Europe. Most member states have cracked down hard on the phenomenon of organized begging with legislation and forceful evictions so the Romani (colloquially known as Gypsies) who are engaged in this venture have moved their business to the country where ...
More News »