They beat like real heart cells, but the rat cardiomyocytes in a dish at Harvard University are different in one crucial way. Snaking through them are wires and transistors that spy on each cell’s electrical impulses. In future, the wires might control their behaviour too.
Versions of this souped-up, "cyborg" tissue have been created for neurons, muscle and blood vessels. They could be used to test drugsMovie Camera or as the basis for more biological versions of existing implants such as pacemakers. If signals can also be sent to the cells, cyborg tissue could be used in prosthetics or to create tiny robots.
"It allows one to effectively blur the boundary between electronic, inorganic systems and organic, biological ones," says Charles Lieber, who leads the team behind the cyborg tissue.
Artificial tissue can already be grown on three-dimensional scaffolds made of biological materials that are not electrically active. And electrical components have been added to cultured tissue before, but not integrated into its structure, so they were only able to glean information from the surface.
Bio-scaffolds go electric
Bioengineers at Harvard University have created the first examples of cyborg tissue: Neurons, heart cells, muscle, and blood vessels that are interwoven by nanowires and transistors. Source
Lieber’s team combined these strands of work to create electrically active scaffolds. They created 3D networks of conductive nanowires studded with silicon sensors. Crucially, the wires had to be flexible and extremely small, to avoid impeding the growth of tissue. The scaffold also contained traditional biological materials such as collagen.
The researchers were able to grow rat neurons, heart cells and muscle in these hybrid meshes. In the case of the heart cells, they started to contract just like normal cells, and the researchers used the network to read out the rate of the beats.
When they added a drug that stimulates heart cell contraction, they detected an increase in the rate, indicating the tissue was behaving like normal and that the network could sense such changes.
Lieber’s team also managed to grow an entire blood vessel about 1.5 centimetres long from human cells, with wires snaking through it. By recording electrical signals from inside and outside the vessel– something that was never possible before– the team was able to detect electrical patterns that they say could give clues to inflammation, whether tissue has undergone changes that make it prone to tumour formation or suggest impending heart disease.
NATO Exercise in Ukraine Coincided with MH-17 Shoot-down 2014 07 24 Rapid Trident was omitted from the flurry of coverage on the shoot-down MH-17.
From the U.S. Army in Europe website:
Rapid Trident supports interoperability among Ukraine, the United States, NATO and Partnership for Peace member nations. The exercise helps prepare participants to operate successfully in a joint, multinational, integrated environment with host-nation support from civil and governmental agencies. ...
Warning of ’imminent’ terror attack in Norway 2014 07 24 Norwegians were warned Thursday of the concrete possibility of a terror attack occurring in that country at the hands of people with connections to an extremist group in Syria.
A press conference was called in Oslo, Norway on Thursday where an announcement was made of a "possible concrete threat" to national security in that country from terrorists related to an extremist ...
Judge says government can access everything in a Gmail account 2014 07 24 All your emails are belong to us.
At least that’s what the latest court order from a judge in New York says. The warrant, granted on June 11, states that the government can access all the content and files contained in a Gmail account.
Yes, this is a significant blow to privacy.
The subject of this specific search relates to a money laundering ...
Air Algerie AH5017 with 116 onboard goes missing for hours, found crashed in Mali 2014 07 24 An Air Algerie flight carrying 110 passengers and six crew members has reportedly crashed in Mali after having disappeared from radar early on Thursday morning between Burkina Faso and Algeria.
A French Ministry of Defense official told Fox News that the two French fighter jets located the wreckage of the plane, which had crashed in Mali. An airport official additionally confirmed ...